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Recommendations when to order or not order the test. May include related or preferred tests.
Use this mass spectrometry test to measure a wide range of estradiol concentrations. Most useful when low estradiol concentrations are expected, regardless of the patient’s sex assigned at birth. Use to monitor estradiol in individuals on estrogen-suppressing hormone therapies (eg, aromatase inhibitors or testosterone).
Indicates whether a test has been approved by the New York State Department of Health.
This test is New York state approved.
Specimen Required
Patient PreparationInstructions patient must follow before/during specimen collection.
CollectSpecimen type to collect. May include collection media, tubes, kits, etc.
Serum separator tube, lavender (EDTA), pink (K2EDTA) or green (sodium or lithium heparin).
Specimen PreparationInstructions for specimen prep before/after collection and prior to transport.
Separate serum or plasma from cells within 2 hours after collection. Transfer 0.5 mL serum or plasma to an ARUP Standard Transport Tube. (Min 0.3 mL) Indicate age and sex of patient on test request form AND specimen tube.
Storage/Transport TemperaturePreferred temperatures for storage prior to and during shipping to ARUP. See Stability for additional info.
Refrigerated.
Unacceptable ConditionsCommon conditions under which a specimen will be rejected.
RemarksAdditional specimen collection, transport, or test submission information.
StabilityAcceptable times/temperatures for specimens. Times include storage and transport time to ARUP.
After separation from cells: Ambient: 48 hours; Refrigerated: 1 week; Frozen: 1 month
Methodology
Process(es) used to perform the test.
Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry
Performed
Days of the week the test is performed.
Sun-Sat
Reported
Expected turnaround time for a result, beginning when ARUP has received the specimen.
1-5 days
Reference Interval
Normal range/expected value(s) for a specific disease state. May also include abnormal ranges.
Test Number
Components
Reference Interval
Estradiol by Mass Spec
Age
Male (pg/mL)
Female (pg/mL)
7-9 years
Less than 7.0
Less than 36.0
10-12 years
Less than 11.0
1.0-87.0
13-15 years
1.0-36.0
9.0-249.0
16-17 years
3.0-34.0
2.0-266.0
18 years and older
10.0-42.0
Premenopausal Early Follicular: 30.0-100.0 Late Follicular: 100.0-400.0 Luteal: 50.0-150.0
Postmenopausal: 2.0-21.0
Tanner Stage I
Less than 8.0
Less than 56.0
Tanner Stage II
Less than 10.0
2.0-133.0
Tanner Stage III
1.0-35.0
12.0-277.0
Tanner Stage IV-V
3.0-35.0
2.0-259.0
Interpretive Data
May include disease information, patient result explanation, recommendations, or details of testing.
For a complete set of all established reference intervals, refer to ltd.aruplab.com/Tests/Pub/0093247.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
The American Medical Association Current Procedural Terminology (CPT) codes published in ARUP's Laboratory Test Directory are provided for informational purposes only. The codes reflect our interpretation of CPT coding requirements based upon AMA guidelines published annually. CPT codes are provided only as guidance to assist clients with billing. ARUP strongly recommends that clients confirm CPT codes with their Medicare administrative contractor, as requirements may differ. CPT coding is the sole responsibility of the billing party. ARUP Laboratories assumes no responsibility for billing errors due to reliance on the CPT codes published.
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
Other names that describe the test. Synonyms.
Estradiol (E2)
Ultrasensitive Estradiol
Estradiol (Adult Males, Children, Postmenopausal Females, or Individuals on Estrogen-Suppressing Hormone Therapy)
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